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This mechanism operates upstream of traditional anti-inflammatory targets

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doi:10.1136/bmj-2021-066452

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Heart Fail Rev Mancini SJ, Boyd D, Katwan OJ, Strembitska A, Almabrouk TA, Kennedy S, Palmer TM, Salt IP (2018) Canagliflozin inhibits interleukin-1-stimulated cytokine and chemokine secretion in vascular endothelial cells by AMP-activated protein kinase-dependent and -independent mechanisms