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112 Renal insufficiency may develop in a patient with cirrhosis as a direct consequence of the underlying condition (i.e., PBC, amyloidosis), as a consequence of excessive diuretic use in the treatment of ascites and fluid overload, or as a secondary reaction to the release of cytokines or hormones by the liver that alter renal function
Contraindications: Hypersensitivity Side Effects: CNS Depression (Sedation) & Bradycardia : The most common adverse effects of clonidine are sedation, dry mouth (xerostomia) , fatigue , bradycardia , dizziness, and constipation (Patel and Saadabadi, 2025
Murine studies also showed that GLP-1 RA might be protective against renal oxidative stress by inhibition of NAD(P)H oxidase and by activation of the cAMP-protein kinase A pathway [48]
"Ankylosis" means fused bones or other hard tissue
