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Moreover, the prolonged exposure to amyloid depositions, has also been found to activate microglia, resulting in excessive secretion of synaptic-toxic cytokines, and tau accumulation that eventually cause synaptic loss and neuronal death (Cao et al., 2019)
Rajagopal Sekhar at Baylor College of Medicine
Our findings clearly lend support to the use of GLP-1 agonists in combination with basal insulin in the clinical management of patients with type 2 diabetes. Victoria Ruszala, a diabetes pharmacist at North Bristol NHS Trust, said that the study provided reassurance about the co-prescription of GLP-1 agonists and basal insulin, already widely practised and endorsed by expert bodies such as the Association of British Clinical Diabetologists
Research does show that side effects are usually more common with tirzepatide especially at higher doses but thats not always the case
W.et al (2023)
