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Peng et al (64) treated neural stem cells (NSCs) with BDNF siRNA, and found that imipramine (IM) increases the neuroprotective effects, suppresses the inflammatory process in NSCs via the modulation of the MAPK pathway and Bcl-2 cascades, indirectly evaluating the anti-inflammatory effect of BDNF

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Endocrine and vagal afferent pathways are involved in these actions of ghrelin and leptin (Inui et al., 2004)

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These interactions activate NF-B through distinct signaling pathways