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On the contrary, multidrug resistance-associated proteins MRP1, MPR4, and MPR5 are not only involved in the uptake of antimalarial drugs but also in the efflux of some metabolites (e.g., oxidized glutathione conjugates and cyclic nucleotides) (Figure 1)

IL-6 as a keystone cytokine in health and disease

Vomiting CVS is characterized by sudden and recurrent episodes of vomiting, which can last for a few hours to several days

Historical GLP-1 research was population-based

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This dual effect could explain why GLP-1 analogues, unlike dexamethasone, improve both synovitis and fibrosis in preclinical models