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doi: 10.1210/clinem/dgaa692 64 LiuXZhangYZhengSYLinRXieYJChenHet al

Its small size and copper-binding affinity underpin its bioactivity, distinguishing it from larger proteins or synthetic peptides

Consequently, it is expected that the rate of diffusion within the tissue postinjection, as well as the transit across the capillary wall, will be reduced due to the increased molecular size of the albumin-peptide complex

Bloodbrain barrier permeability is induced in AOM mice via a mechanism involving the TGF 1-driven SMAD3-dependent upregulation of MMP9 expression and decrease of claudin-5 expression

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That's not a dismissal of the work, it's a realistic assessment of where the science currently stands and where formal investment could accelerate progress