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Women should consider using non-oral contraceptives or adding barrier methods for 4 weeks after starting tirzepatide or after each dose increase Insulin or sulphonylureas concomitant use increases hypoglycaemia risk

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While a slow gradual decline in serum testosterone with age has been well documented, the combination of low testosterone and sexual symptoms in a study of 2,966 males aged 40 to 79 indicated that the incidence of hypogonadism in older men is relatively low (~2.1 percent)(Tajar et al 2012)