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In muscle tear models, the combination addresses both the inflammatory response and the structural repair phase simultaneously with BPC-157 modulating pro-inflammatory cytokines (TNF-, IL-6) and oxidative stress markers, and TB-500 recruiting progenitor cells and mesenchymal cells to the post-injury site while BPC-157 drives their subsequent differentiation and organisation

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Proline and its hydroxylated form, hydroxyproline, constitute approximately one-third of collagen, making proline availability a limiting factor for collagen synthesis and ECM accumulation [13,14,15,16]

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