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Modulation of Oxidative Stress as an Anticancer Strategy

Moreover, mP-NPs-DNase/PTX nanoparticles consisting of a paclitaxel (PTX) prodrug nanoparticle core and a poly-l-lysine (PLL) conjugated with the matrix metalloproteinase 9 (MMP-9)-cleavable Tat-peptide-coupled deoxyribonuclease I (DNase I) shell can inhibit malignant tumor growth and distant metastasis by releasing DNase I responsive MMP-9 and further degrading the structure of tumor associated neutrophil extracellular traps after accumulation at the tumor site (113)

(2024) 109:e61322