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Senescent VECs exhibit a distinctive profile characterized by reduced expression of nitric oxide (NO) and an elevation in reactive oxygen species (ROS) (73)

An earlier controlled study (Coviello 2005) showed that low-dose HCG maintained intratesticular testosterone in a dose-dependent way when the body's own gonadotropins were suppressed the mechanistic basis for using it during testosterone therapy

doi: 10.1021/ic3022672

Understanding why medications fall short clarifies why durable pain relief depends on restoring the biological systems responsible for healingrather than escalating suppression

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An increase in spine density that was attributable to a reduction of spine pruning was found in the dentate gyrus in mice given LPS on E15 (226) and in the hippocampus in mice that were given 2 doses of poly(I:C) on E12.5 and E17.5 (211)