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Factors like your genetics, underlying insulin resistance, hormonal imbalances (especially common in women!), other medications you might be taking, your sleep quality, and even your stress levels can all profoundly affect how you respond to GLP-1 medication

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The downside is that it does involve one or more incisions on the uterus

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"Semaglutide and Cardiovascular Outcomes in Patients with Type 2 Diabetes." The New England Journal of Medicine, 2016