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2.2 Literature screening and data extraction Two independent researchers manually screened the titles and abstracts of all studies to ensure relevance to the study topic, resolving discrepancies through discussion to maintain rigor in the selection process
A panel of reference ligands representing diverse chemotypes including TT-OAD2, PF-06882961 (danuglipron), LY3502970 (orforglipron), CHU-128, GSBR-1290 (aleniglipron), and AZD5004 (Figure 2) was used to derive the ligand-centered models described below
Additionally, 67.8% of those receiving Semaglutide experienced a weight reduction of 5% or more at week 104, compared to just 21.3% in the control group
