Upon release, Nrf2 translocates to the nucleus and binds to the antioxidant response element (ARE) located in the promoter of genes coding for antioxidant/detoxifying enzymes and scavengers
Riboflavin contributes to the protection of cells from oxidative stress
Loss of proteostasis Proteostasis refers to the dynamic balance of a complex network of proteins in cells, including protein synthesis, structural and functional maturation, protein quality control, folding modification, localization and transport, functional recovery and degradation
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Nevertheless, our review revealed that complete or overall tumor response fluctuates across different cases
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