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Glutathione suppresses tyrosinase in three ways: direct inhibition through chelation of copper, interference with the transfer of tyrosinase to premelanosomes, tyrosinase inhibition indirectly by antioxidant effect

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In GBM, metabolic reprogramming via upregulation of PHGDH and SHMT2 has been found to provide a survival advantage under hypoxic and nutrient-deprived conditions