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In addition, heterotopic tumors from CreERT2 mice showed diminished inflammation demonstrated by reduced presence of total leukocytes (CD45 + area), TAMs (CD68 + area), neutrophils (MPO + cells), tumor-infiltrating lymphocytes, TILs (FOXP3 + ), as well as T regulatory cells, Tregs (FOXP3 + CD4 + cells)

Placental inflammation can induce oxidative stress, resulting in an overproduction of free radicals/ROS and reduced antioxidant ability ( Figure 4 ) (113)

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10.1016/j.bbrc.2016.10.086 58 GillI.ValivetyR