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In addition, a high degree of interest or evidence of use in practice also is considered in deciding whether to include an off-label listing

They are capable of distinguishing healthy cells from aberrant cells, the latter often exhibiting downregulated or absent major histocompatibility complex (MHC) class I molecules (226)

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Finally, though glucose use for fatty acid synthesis is strongly suppressed in the absence of ACLY, it is not fully blocked in vitro or in vivo 4,6