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Gastrocnemius recession and surgical debridement may be performed at the same time

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Therefore, considering that PCa is often classified as a cold tumor with a suppressed immune microenvironment, merely promoting apoptosis in PCa cells may not yield satisfactory clinical outcomes

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Identify gaps in the literature and ongoing research directions Key gaps include a lack of large, controlled clinical trials, unclear optimal dosing and delivery for reproductive targets, limited long-term safety data for systemic use, and few mechanistic human studies linking molecular changes to fertility outcomes

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