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On top of doing some of the heavy lifting directly, vitamin C can also interact with other antioxidant players, including antioxidant enzymes (specialized proteins involved in mitigating the effects of oxidative stress), and regulate gene expression related to antioxidant defense
Lancet 1:289291 Sitta A, Vanzin CS, Biancini GB, Manfredini V, de Oliveira AB, Wayhs CA, Ribas GO, Giugliani L, Schwartz IV, Bohrer D, Garcia SC, Wajner M, Vargas CR (2011) Evidence that l-carnitine and selenium supplementation reduces oxidative stress in phenylketonuric patients
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Studies have shown that it can resist the toxicity of APAP to hepatocytes by activating Nrf2
Systemic supplementation: Oral or intravenous supplementation with glutathione or its precursors (such as N-acetylcysteine) can increase systemic GSH levels, enhancing the overall antioxidative capacity of the body