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A key initiating factor in the disruption of this axis is leaky gut, which allows the translocation of microbial-derived products, such as LPS, trimethylamine-N-oxide (TMAO), ethanol, bile acids, and short-chain fatty acids (SCFAs), into the portal circulation (221)

doi: 10.1038/ijo.2017.88

Apart from reward, this initial AUD phase is influenced by the motivation to consume alcohol, which is another factor controlled by GLP-1R in male rats