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Unlike steroids, peptides are hydrophilic and bind to surface receptors such as G-protein-coupled receptors (GPCRs) to trigger internal signaling cascades without entering the cell nucleus

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Post-CD73 deletion, less cell movement was seen by wound healing experiments, accompanied by lower phosphorylation of ERK and STAT3, and elevated E-cadherin expression, indicating the inhibition of critical oncogenic pathways and the amplification of tumor-suppressor signaling

Studies looking at the direct infusion of PregS into the nucleus basalis show that this neurosteroid improves spatial memory function in rats and increases acetylcholine release in the basolateral amygdala and frontoparietal cortex (196)

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