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Liver dysfunction does not explain every mood or cognitive symptom, but oxidative stress, altered medication metabolism, gut-derived inflammation, ammonia, copper imbalance, low glutathione and impaired methylation may reduce neurological resilience in selected patients

Cell 123 (3), 493505 (2005)

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However, clinical studies specifically in alcohol-using populations will be necessary to validate these applications

Details of the technique and the examination procedure for LSM have been described previously [15, 16]

This converts all the water in the solution to ice while preserving the peptide structure within the ice matrix