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Lastly, a deficiency in vitamin B12 can lead to the inability to lose weight and keep it off for good

Hemoglobin A1c: 3-month average glucose control

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That includes one of the most important: the immune system

[1] Additionally, the authors indicate that there is still a requirement for successful human trials to be completed prior to clinical translation as there are important differences between rodent and human physiology that could have a significant impact on the efficacy and safety of any agent