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Targeting the APLN pathway with antagonists like ML221 has been shown to alleviate BTB damage and improve sperm quality in diabetic mice [54]

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Huang, K., Qiu, H., Liao, D., Jiang, Y., Deng, Y., & Chen, H

Paracrine regulation of insulin secretion

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However, elevated cholesterol levels contribute to nonalcoholic fatty liver disease (NAFLD) and are known risk factors for cardiovascular disease (CVD) [4]