Past oral B12 supplements didnt help due to impaired absorption
Insulin Sensitivity Research Research has examined potential relationships between NNMT inhibition and insulin sensitivity in metabolic research models
When NNMT activity is high, research models report: reduced NAD availability for mitochondrial energy production
As fat tissue grows and more NNMT is produced, higher amounts of hormones and pro-inflammatory signals are produced that are responsible for weight gain and other chronic diseases such as type 2 diabetes and cardiovascular disease. NNMT is responsible for converting nicotinamide (NA) into 1-methylnicotinamide (1-MNA), which takes it out of the NAD salvage pathway (see the diagram below)
Vitamin B12 supplements Cobalamin compounds such as cyanocobalamin and hydroxycobalamin are commonly given as supplements
Vitamins B1, B6, and B12 are clinically proven nerve nourishing B vitamins, they help to protect & nourish the nerves