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After CTP modification, there was a new band at 1249 cm 1 ( C-N ), together with distinct stretching vibrations at 1644 and 1343 cm 1 (C = O, CTP), belonging to the O = C-N-H group connecting the PEG and CTP moieties, confirming the successful combination of TP-10@CaP-DSPE-PEG with CTP by the EDC/NHS reaction

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