Flavonoid compounds, including epigallocatechin gallate (84), quercetin (85), aloesin (86,87), hydroxystilbene derivates and licorice extracts are used for hyperpigmentation due to the ability to remove ROS and to chelate metals ions at the active sites of metalloenzymes (88)
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Its ability to bind to heavy metals is attributed to a specific structural component called rhamnogalacturonan II , which possesses strong metal-chelating properties
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Congested blood vessels were also encountered
NNMT metabolizes nicotinamide into 1-methylnicotinamide (MNA), diverting it away from the NAD+ salvage pathway