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The activity of APX increased by GSH treatment to plants

Blood glutathione disulfide: in vivo factor or in vitro artifact

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The copper binding occurs through a square-planar pyramid configuration involving nitrogen from histidines imidazole side chain, nitrogen from glycines alpha-amino group, deprotonated amide nitrogen of the glycine-histidine peptide bond, and carboxyl oxygen from lysine

Mechanism of Action: GHK-Cu promotes tissue repair and regeneration by influencing gene expression related to tissue remodeling, collagen synthesis, and angiogenesis (new blood vessel formation)