The 2-minute half-life cited in the body of this article is what survives that first pass
Beware of claims like Lose 50 pounds in 6 weeks! or No diet or exercise needed! GLP-1s are effective but work gradually over months, and theyre most successful when combined with lifestyle changes
This tool is intended for: This calculator is a screening and education tool
Weeks 9 through 12: 4 mg weekly What is happening: This is where retatrutide starts to differentiate itself from single and dual-agonist compounds
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OBESITY AND IBD by @EdwardLoftus2 Obesity is a chronic inflammatory statue Adipose tissue is not biologically inert (TNFa, IL-6, IL-8, leptin, adiponectin) Postulated role in the pathogenesis of IBD Potential risk factor for adverse outcomes Trends in BMI among IBD patients at diagnosis in Olmsted County, Doubling of obesity rates in 20 years in CD and UC (Johnson AM JCC 2021 and J Clin Gastro 2024) Obese patients more likely to have a colonic phenotype