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Those who have successfully implemented sustainable changesincluding regular physical activity (UK Chief Medical Officers recommend at least 150 minutes of moderate-intensity activity weekly), improved dietary patterns, and behavioural strategies for weight managementmay have better outcomes if discontinuing GLP-1 therapy
Future Directions: Research is expanding beyond weight loss to evaluate CagriSema's effects on cardiometabolic complications (cardiovascular disease, NASH, sleep apnea, HFpEF), special populations (adolescents, diverse ethnic groups), and quality of life outcomes
But expecting double-digit weight loss from supplements marketed as GLP-1 boosters will lead to disappointment
doi: 10.1074/jbc.M703324200 20 IlagL
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