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Gossypol acetic acid attenuates cardiac ischemia/reperfusion injury in rats via an antiferroptotic mechanism

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Brain slice electrophysiology Mice were anaesthetized with isoflurane and then perfused with ice-cold oxygenated N-Methyl-D-glucamine (NMDG) artificial cerebrospinal fluid (ACSF) (20 mL) that contained (in mM): KCl (2.5), NMDG (93), NaHCO (30), NaHPO (1.2), glucose (25), HEPES (20), thiourea (2), Na-pyruvate (3), CaCl (0.5), Na-ascorbate (5), MgSO (10), and glutathione (3) (pH 7.37.4, 300305 mOsm)

This argues that the company either knew or should have known about the risk of the particular injury

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In the meantime, creative market solutions can expand access to these drugs