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Evidence indicates that the best time to take supplements is right before exercise, ideally 30 to 60 min beforehand, as this aligns peak bioavailability with exercise-induced metabolic and anti-inflammatory pathways, including SIRT1 and AMPK activation, and maximizes their synergistic effects (114, 155)

Poulia, K

It's a clear-eyed "we have strong signals and not yet the definitive proof." I'd rather hand you that than a fairy tale

If your baseline synthesis is inadequate, that's a chronic metabolic issue, not a consequence of supplementation

Acetyl-L-Carnitine: Often called ALCAR, this is possibly the most effective form for your brain

They are delicate