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Laboratory investigation should include complete blood count, ferritin, thyroid function, and other tests based on clinical suspicion

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Furthermore, with large-scale drug use it is inevitable that PZQ-resistant parasites will evolve, and PZQ resistance has been induced in laboratory infections 12

Small human trials have not revealed significant toxicity, but they also lack rigorous design and long-term surveillance

They are usually dimers, but occasionally tetramers

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