human glp-1 sequence Designing a dual GLP-1R/GIPR agonist from tirzepatide | DDDT Peptide sequences and molecular structures

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15,22 Comprehensively, using Aib 2 is likely to only minimally influence the GLP-1 and GIP activities

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25 Both affinity and activity reduce 10-fold if the Arg 36 of GLP-1 is cut away, 41 showing that it is crucial for interaction

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