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doi: 10.1056/NEJMoa2204705 177 MindellJ

Endothelial function is associated with pulse pressure, pulse wave velocity, and augmentation index in healthy humans

As positive control, we exposed cells to the GSH-synthesis inhibitor L-buthionine-sulfoximine (L-BSO), which was shown to induce oxidative stress but not cytotoxicity in HCT116 cells 24, 25

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Additionally, while proponents argue that small molecules are cheaper to manufacture than biologics, whether those savings will be passed on to the patient or simply absorbed into the profit margins remains to be seen, with projected self-pay costs in some cases exceeding $1,000 per month