The catalytic parameters and substrate specificity of GPx6 are not known as the protein has not been purified yet [1, 8]
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Base-case and sensitivity analyses In Table 3, using three times Taiwans GDP as the WTP threshold (US$77,679), the base-case analysis indicated that using a GLP-1RA versus insulin was cost-effective for preventing one case with all-cause mortality or hospitalized hypoglycemia from the payer perspective, and cost-saving from the healthcare sector perspective
Real-world use introduces broader populations, comorbidities, and long-term exposure, making continuous safety monitoring essential
The practical result is that some patients need closer monitoring or provider-led adjustment during the steroid course
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