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In that study, single-point alanine replacements at positions 8, 9, 15, 22, and 28 produced analogues 26 times more potent than the hGHRH(1-40)-OH standard, whereas alanine substitution at positions 1, 3, 5, 6, 10, 11, 13, 14, and 23 caused nearly complete loss of potency

Lu J, Cai L, Wu Z, et al

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further demonstrated the modulatory role of BPC 157 on nitric oxide generation 7,8,9,10,11

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