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[1] Monitoring in diabetes : Patients with diabetes who are taking insulin or sulfonylureas should monitor their blood glucose levels closely when starting ispaghula, as improved glycaemic control may necessitate adjustments to these medications

doi: 10.1038/s41418-022-01051-7 64 LiZLiYYangYGongZZhuHQianY

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If the volume was adequate and the powder still will not dissolve, allow the vial to stand at room temperature for a further 1015 minutes and swirl again periodically