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A 2025 joint advisory issued by the American College of Lifestyle Medicine, the American Society for Nutrition, the Obesity Medicine Association, and the Obesity Society recommended that individuals undergoing active weight reduction aim for 1.2 to 1.6 grams of protein per kilogram of body weight daily, with some experts suggesting that setting an absolute target of 80 to 120 grams per day may enhance adherence while ensuring adequate intake (Mozaffarian et al.)

Tapering may be helpful if using long term (6+ weeks), but isnt physiologically necessary

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It is not evident whether these beneficial effects of GLP-1 agonists are secondary to weight loss or due to direct cardiac actions

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Ketosis and appetite-mediating nutrients and hormones after weight loss