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Peer review Peer review information Nature Communications thanks Wei Du, Xiaoqing Tang, and the other anonymous reviewer(s) for their contribution to the peer review this work

Activation of AMPK in skeletal muscle increases translocation of glucose transporter 4 (GLUT4) to the cell membrane, thereby increasing glucose uptake (Figure 2)

Consult a health care practitioner prior to use if you are taking nitroglycerin, acetaminophen, iron supplements or if you have gout

5 Synergistic therapy and clinical translation The significant interindividual variability in SFN response is not a barrier but an opportunity for precision medicine

Kang, B