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[PubMed] [Google Scholar] 63.Shahani KM, Ayebo AD

Management goals are to decrease the risk for developing melanoma by surgical removal and to produce good cosmetic results

others described difficulty reaching their prescriber when side effects arose or when they needed a dose adjustment

However, a 2025 review noted only 3 RCTs, calling for larger trials (Nguyen et al., 2025)

Cost-benefit at scale: If millions use retatrutide for years, do the cardiovascular and diabetes prevention benefits outweigh the side effect burden and $15,00018,000 annual cost