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10.3390/ph11040127 Pharmaceuticals 38 KhaliliM.EbrahimzadehM.KosaryanM

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In preclinical models, BPC157 has been shown to modulate expression of key inflammatory mediators by downregulating proinflammatory transcription factors such as NFB and AP1 while upregulating antiinflammatory genes linked to IL10 signaling, thereby shifting the balance toward resolution of inflammation in chronically injured tissues (24,25)

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The carboxy-terminal Neh3 domain of Nrf2 is required for transcriptional activation