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A 2024 metabolism study added another layer of complexity

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In the STEP-4 randomized trial (Rubino and colleagues, JAMA, 2021), the 803 adults who switched to placebo at week 20 regained about 6.9 percent of body weight over the next 48 weeks, while those who continued semaglutide kept losing

Cancer interaction : Could enhanced cell proliferation affect tumor growth in predisposed individuals

However, comprehensive long-term human safety data does not exist