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Oral semaglutide for weight loss and liver fibrosis in overweight and obesity: A randomized controlled trial

Other reported effects Beyond GI symptoms, clinical trials noted several other effects worth monitoring: Increased heart rate: A small, dose-dependent increase in resting heart rate was observed, consistent with what occurs with other GLP-1 agonists

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Overall, the introduction of the new obesity pharmacotherapies may shift the focus of the multidisciplinary team on nutrition support during the rapid WL phase and on behavioural changes aiming to support long-term weight maintenance, similar to what is the focus after bariatric surgery