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The sponsor conducted several scenario analyses on each modelled population, including taking a taking a societal perspective, omitting discounting, increasing the discount rate to 3%, using a 20-year time horizon, changing the threshold for intensification treatment to 8.5% from 8%, and using the number of years associated with the initial treatment as opposed to using hemoglobin A1C as a threshold for intensification (i.e., the intensification trigger threshold was 4 years for second-line treatment and 5 years for third-line treatment)

Reference lists of pertinent papers were also examined to ensure inclusion of additional relevant works

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Herbal formulas (such as those listed in Table 1) are commonly used in in various academic centers in the West (such as the Memorial Sloan-Kettering Cancer Center [51], University of California, Los Angeles [52], University of California San Francisco [53], Cleveland Clinic [54], and Cornell University [55])