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So-called non-responders are people who lose less than 5 percent of their body weight after roughly six months of treatment on the highest tolerated dose

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We nevertheless observed, by RICCS analysis, a tendency for reduced co-diffusion of Laurdan with GLP-1R V229A under vehicle conditions, an effect normally only present in stimulated conditions for WT receptor, with no further change after agonist stimulation observed for the V229A mutant, suggesting a different pattern of interaction of V229A versus WT GLP-1R with plasma membrane lipids

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Here are a few more details on specific strains in this group

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