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In the STEP trials (Semaglutide Treatment Effect in People with Obesity), participants who reached the 2.4 mg maintenance dose lost an average of 1518% of baseline body weight over 68 weeks, compared to 46% loss at lower doses and 23% with placebo

In this context, recent EULAR Points to Consider emphasize the importance of recognizing clinical and imaging features suggestive of progression from PsO to PsA, including arthralgia, enthesitis, subclinical synovitis on ultrasound or MRI, and elevated inflammatory markers (12)

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Ghusn W, De la Rosa A, Sacoto D, et al

And that's important because getting out there in the community is key to building that trust

Lesion of the lateral parabrachial nucleus attenuates the anorectic effect of peripheral amylin and CCK