Given that cytosolic CRAT-generated acetyl-CoA can produce malonyl-CoA, an inhibitor of fatty acid oxidation [1, 33], we speculate that, in addition to the suppression of mitochondrial biogenesis by increasing acetyl-CoA-mediated acetylation of PGC-1, the anti-tumoral activity of CRAT may also be partially achieved by inhibiting fatty acid oxidation, which still needs further investigation
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[DOI] [PMC free article] [PubMed] 16.Drucker DJ
The results suggested that while both medications were associated with weight loss and improved glycemic outcomes, the cost-effectiveness ratio of Tirzepatide was more favorable