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The Nrf2-Keap1 defence pathway: role in protection against drug-induced toxicity

doi: 10.1038/377646a0 102 TennantMKThrasherJBTwomeyPABirnbaumRSPlymateSR

Importantly, of all the metabolites that significantly distinguished +ADT from ADT group, the only metabolite that significantly correlated with PROMIS-SRI sleep impairment T -scores was androsterone sulfate, which is a metabolic endpoint marker of the effectiveness of ADT in reducing circulating androgens (Mong et al., 2011)

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