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71 In HPP, deficiency or dysfunction of TNSALP disrupts the metabolism of PLP leading to alteration of both extracellular and intracellular PLP levels

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In general pharmacology, titration means making cautious, incremental changes while monitoring tolerance , because faster changes can increase the likelihood of adverse effects

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[DOI] [PubMed] [Google Scholar] 88.Dorner B.G., Zeleny R., Harju K., Hennekinne J.A., Vanninen P., Schimmel H., Rummel A