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Importantly, these studies demonstrate a consistent pattern: whilst retained gastric contents are significantly more common in GLP-1 RA users, the absolute rates vary considerably depending on patient factors, medication duration, and assessment methods [35]

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Another approved treatment is phentermine/topiramate, a combination of a sympathomimetic appetite suppressant (phentermine) and an anticonvulsant (topiramate), which acts as a centrally acting neuromodulator to reduce appetite and promote weight loss

Central insulin and insulin-like growth factor-1 signaling: implications for diabetes associated dementia

Studies suggest that using a PEG tube at the right time may extend life by 36 months (Guillemin et al., 2022)

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